Equid exfoliating sole and insensitive frog has no enervation or vascularity and is comprised mainly of collagen, which is a major component of the extracellular matrix that supports most tissues and gives cells structure from the outside. The primary function of the exfoliating sole and insensitive frog is to protect their sensitive analogs from concentrated environmental pressure. The aldehyde and tannic acid in Durasole create crosslinks with collagen and other forms of protein in the exfoliating sole and insensitive frog on the solar surface of the equid hoof by forming covalent bonds between adjacent amine containing groups. Crosslinking, the formation of larger molecules from the smaller molecules of the exfoliating sole and insensitive frog, greatly enhances the protective properties of the respective structures by increasing both their mechanical stability and structural integrity. 

Durasole is formulated to be an extremely effective sole toughener; additionally, Durasole contains povidone-iodine in sufficient concentration to be effective in the treatment of thrush when aerobic conditions are maintained at the infection site and is of value in the fixing of laminar tissue exposed by the removal of infected hoof wall.